The Safe Pulmonary Embolism Emergency Department Discharge (SPEED-D) study was a prospective observational study of ED patients that identified clinical traits associated with the need for hospitalization after a PE diagnosis. SPEED-D was used to inform the creation of the Outpatient PE treatment protocol later studied in the Outpatient PE Study. Many SPEED-D patients also contributed blood samples that are housed in the CVE Biorepository.


Metabolomic analysis of 92 pulmonary embolism patients from a nested case-control study identifies metabolites associated with adverse clinical outcomes.

Zeleznik OA, Poole EM, Lindstrom S, Kraft P, Van Hylckama Vlieg A, Lasky-Su JA, Harrington LB, Hagan K, Kim J, Parry BA, Giordano N, Kabrhel C.J Thromb Haemost. 2018 Mar;16(3):500-507. doi: 10.1111/jth.13937. Epub 2018 Jan 30.PMID: 29285876

Relation Among Clot Burden, Right-Sided Heart Strain, and Adverse Events After Acute Pulmonary Embolism.

Hariharan P, Dudzinski DM, Rosovsky R, Haddad F, MacMahon P, Parry B, Chang Y, Kabrhel C.Am J Cardiol. 2016 Nov 15;118(10):1568-1573. doi: 10.1016/j.amjcard.2016.08.025. Epub 2016 Aug 24.PMID: 27742425

Assessment of Right Ventricular Strain by Computed Tomography Versus Echocardiography in Acute Pulmonary Embolism.

Dudzinski DM, Hariharan P, Parry BA, Chang Y, Kabrhel C.Acad Emerg Med. 2017 Mar;24(3):337-343. doi: 10.1111/acem.13108.PMID: 27664798

Association between electrocardiographic findings, right heart strain, and short-term adverse clinical events in patients with acute pulmonary embolism.

Hariharan P, Dudzinski DM, Okechukwu I, Takayesu JK, Chang Y, Kabrhel C.Clin Cardiol. 2015 Apr;38(4):236-42. doi: 10.1002/clc.22383. Epub 2015 Apr 2.PMID: 25847482

A comparison of patients diagnosed with pulmonary embolism who are ≥65 years with patients <65 years.

Cefalo P, Weinberg I, Hawkins BM, Hariharan P, Okechukwu I, Parry BA, Chang Y, Rosovsky R, Liu SW, Jaff MR, Kabrhel C.Am J Cardiol. 2015 Mar 1;115(5):681-6. doi: 10.1016/j.amjcard.2014.12.025. Epub 2014 Dec 18.PMID: 25586333

Factors associated with clinical deterioration shortly after PE.

Kabrhel C, Okechukwu I, Hariharan P, Takayesu JK, MacMahon P, Haddad F, Chang Y.Thorax. 2014 Sep;69(9):835-42. doi: 10.1136/thoraxjnl-2013-204762. Epub 2014 May 20.PMID: 24846902

Patient preferences for testing for pulmonary embolism in the ED using a shared decision-making model.

Geyer BC, Xu M, Kabrhel C.Am J Emerg Med. 2014 Mar;32(3):233-6. doi: 10.1016/j.ajem.2013.11.019. Epub 2013 Nov 14.PMID: 24370071

Association between the Pulmonary Embolism Severity Index (PESI) and short-term clinical deterioration.

Hariharan P, Takayesu JK, Kabrhel C.Thromb Haemost. 2011 Apr;105(4):706-11. doi: 10.1160/TH10-09-0577. Epub 2011 Jan 12.PMID: 21225095

Outcomes considered most important by emergency physicians when determining disposition of patients with pulmonary embolism.

Kabrhel C, Sacco W, Liu S, Hariharan P.Int J Emerg Med. 2010 Oct 19;3(4):239-64. doi: 10.1007/s12245-010-0206-8.PMID: 21373290

12-lead ECG findings of pulmonary hypertension occur more frequently in emergency department patients with pulmonary embolism than in patients without pulmonary embolism.

Marchick MR, Courtney DM, Kabrhel C, Nordenholz KE, Plewa MC, Richman PB, Smithline HA, Kline JA.Ann Emerg Med. 2010 Apr;55(4):331-5. doi: 10.1016/j.annemergmed.2009.07.025. Epub 2009 Sep 19.PMID: 19766353