The Outpatient PE study is a multi-center observational study of more than 3000 consecutive emergency department that demonstrated the safety and efficacy of outpatient PE treatment. Patients in the Outpatient Study were diagnosed with acute PE, underwent risk stratification, anticoagulation and were followed for 30 days after diagnosis. Following the implementation of our outpatient PE treatment protocol, approximately 25% of patients with low-risk PE were safely treated without the need for hospitalization.


A clinical decision framework to guide the outpatient treatment of emergency department patients diagnosed with acute pulmonary embolism or deep vein thrombosis: Results from a multidisciplinary consensus panel.

Kabrhel C, Vinson DR, Mitchell AM, Rosovsky RP, Chang AM, Hernandez-Nino J, Wolf SJ.J Am Coll Emerg Physicians Open. 2021 Dec 15;2(6):e12588. doi: 10.1002/emp2.12588. eCollection 2021 Dec.PMID: 34950930

Multicenter Implementation of a Novel Management Protocol Increases the Outpatient Treatment of Pulmonary Embolism and Deep Vein Thrombosis.

Kabrhel C, Rosovsky R, Baugh C, Connors J, White B, Giordano N, Torrey J, Deadmon E, Parry BA, Hagan S, Zheng H.Acad Emerg Med. 2019 Jun;26(6):657-669. doi: 10.1111/acem.13640. Epub 2018 Nov 29.PMID: 30341928

Emergency Department Discharge of Pulmonary Embolus Patients.

Frank Peacock W, Coleman CI, Diercks DB, Francis S, Kabrhel C, Keay C, Kline JA, Manteuffel J, Wildgoose P, Xiang J, Singer AJ.Acad Emerg Med. 2018 Sep;25(9):995-1003. doi: 10.1111/acem.13451. Epub 2018 Jun 11.PMID: 29757489

The creation and implementation of an outpatient pulmonary embolism treatment protocol.

Kabrhel C, Rosovsky R, Baugh C, Parry BA, Deadmon E, Kreger C, Giordano N.Hosp Pract (1995). 2017 Aug;45(3):123-129. doi: 10.1080/21548331.2017.1318651. Epub 2017 Apr 21.PMID: 28402686

Multicenter Trial of Rivaroxaban for Early Discharge of Pulmonary Embolism From the Emergency Department (MERCURY PE): Rationale and Design.

Singer AJ, Xiang J, Kabrhel C, Merli GJ, Pollack C, Tapson VF, Wildgoose P, Peacock WF.Acad Emerg Med. 2016 Nov;23(11):1280-1286. doi: 10.1111/acem.13072. Epub 2016 Oct 31.PMID: 27537530

The Outpatient Treatment of Venous Thromboembolism: Operational Impact and the Role of Novel Anticoagulants.

White B, Rosovsky R, Parry BA, Kabrhel C.Semin Thromb Hemost. 2016 Nov;42(8):846-856. doi: 10.1055/s-0036-1593542. Epub 2016 Oct 20.PMID: 27764882